YK-4-279

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Chemical Information

Product name：YK-4-279	Purity：98% min
CAS NO：1037184-44-3	Solubility：DMSO: 73 mg/mL (199.34 mM)
Molecular Formula：C₁₇H₁₃Cl₂NO₄	Package：Package according to customer requirements
Molecular Weight：366.195	Storage：Store at -20℃

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Remarks

YK-4-279 is a ETV1 inhibitor, which inhibitor protein-protein interactions between ES-FLI1 and RHA.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model. YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. YK-4-279, prevents prostate cancer growth and metastasis in a mouse xenograft model.

Related Prodcuts:

Doxorubicin HCl; Epirubicin; Epirubicin HCl; Idarubicin HCl; Pirarubicin; Amrubicin; Amrubicin HCL; AMG 900; AT-7519 HCL; Belinostat; Resminostat; Resminostat hydrochloride; Mizoribine; Daunorubicin hydrochloride

References

[1]. Barber-Rotenberg JS, et al. Single enantiomer of YK-4-279 demonstrates specificity in targeting the oncogene EWS-FLI1. Oncotarget. 2012 Feb;3(2):172-82.

[2]. Rahim S, et al. YK-4-279 inhibits ERG and ETV1 mediated prostate cancer cell invasion. PLoS One. 2011 Apr 29;6(4):e19343.