Fingolimod, also known as FTY720, is an immunosuppressive drug. It is derived from the myriocin (ISP-1) metabolite of the fungus Isaria sinclairii. It is a structural analogue of sphingosine and gets phosphorylated by sphingosine kinases in the cell (most importantly sphingosine kinase. The molecular biology of phospho-fingolimod is thought to lie in its activity at one of the five sphingosine-1-phosphate receptors, S1PR1.
Synonyms:
FTY720 Hydrochloride;
Fingolimod HCl/FTY720;
2-Amino-2-(4-octylphenethyl)propane-1,3-diol hydrochloride;
2-Amino-2-[2-(4-octyl-phenyl)-ethyl]-propane-1,3-diol hydrochloride Fingolimod hydrochloride;
2-Amino-2-[2-(4-n-octylphenyl)ethyl]propane-1,3-diol Hydrochloride;
Properties:
Appearance & Physical State: white solid
Density: 1.016g/cm3
Boiling Point: 479.5ºC at 760 mmHg
Melting Point: 102-107ºC
Flash Point: 243.8ºC
Refractive Index: 1.531
Vapor Pressure: 5.28E-10mmHg at 25°C
S1P Receptor Inhibitors Related Products:
JTE-013; Ponesimod; Ozanimod