Cutamesine dihydrochloride

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Chemical Information

Product name：Cutamesine dihydrochloride	Purity：99% min
CAS NO：165377-44-6	Solubility：DMSO : 30 mg/mL (67.96 mM)
Molecular Formula：C₂₃H₃₄Cl₂N₂O₂	Package：Package according to customer requirements
Molecular Weight：441.434	Storage：Store at -20℃

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Remarks

Cutamesine, also known as SA-4503 and AGY94806, is a sigma-1 receptor agonist under development for recovery enhancement after acute ischemic stroke. Cutamesine protects against retinal cell death in vitro and in vivo by the agonistic effect of sigma-1 receptor. Therefore, sigma-1 receptor may have a potential as a therapeutic target in retinal diseases mediated by photoreceptor degeneration.

Cutamesine dihydrochloride (SA4503 dihydrochloride; AGY94806 dihydrochloride) is a potent Sigma 1 receptor agonist with an IC50 of 17.4 nM in guinea pig brain membranes.

Properties:
Boiling Point: 499.2ºC at 760 mmHg
Flash Point: 137.3ºC
Vapor Pressure: 4.25E-10mmHg at 25°C

Sigma Receptor Related Products:

Siramesine HCl; Blonanserin; S1RA(E-52862); Siramesine(Lu 28-179); S1RA hydrochloride

References

[1]. Lever JR, et al. Sigma1 and sigma2 receptor binding affinity and selectivity of SA4503 and fluoroethyl SA4503. Synapse. 2006 May;59(6):350-8.

[2]. Tuerxun T, et al. SA4503, a sigma-1 receptor agonist, prevents cultured cortical neurons from oxidative stress-induced cell death via suppression of MAPK pathway activation and glutamate receptor expression. Neurosci Lett. 2010 Jan 29;469(3):303-8.