Lu 28-179 Siramesine

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Chemical Information

Product name：Lu 28-179 Siramesine	Purity：98% min
CAS NO：147817-50-3	Solubility：Soluble in DMSO
Molecular Formula：C₃₀H₃₁FN₂O	Package：Package according to customer requirements
Molecular Weight：454.578	Storage：Store at -20℃

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Remarks

Siramesine, also known as Lu-28-179, is a potent sigma-2 receptor agonist. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Siramesine is a lysosomotropic detergent that induces cytoprotective autophagosome accumulation. Siramesine involves lysosomal leakage and oxidative stress.

Sigma Receptor Related Products:

Siramesine HCl; Cutamesine dihydrochloride; Blonanserin; S1RA(E-52862); S1RA hydrochloride

References

[1]. Cesen MH, et al. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Dis. 2013 Oct 3;4:e818.

[2]. Spirkoski J, et al. Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist. Biochem Pharmacol. 2012 Dec 15;84(12):1671-80.