Siramesine HCl

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Chemical Information

Product name：Siramesine HCl	Purity：98% min
CAS NO：224177-60-0	Solubility：DMSO : ≥ 42 mg/mL (85.53 mM)
Molecular Formula：C₃₀H₃₂ClFN₂O	Package：Package according to customer requirements
Molecular Weight：491.039	Storage：Store at -20℃

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Remarks

Siramesine (Lu 28-179) hydrochloride is a potent sigma-2 receptor agonist. Siramesine hydrochloride has a subnanomolar affinity for sigma-2 receptors (IC50=0.12 nM) and exhibits a 140-fold selectivity for sigma-2 receptors over sigma-1 receptors (IC50=17 nM). Siramesine hydrochloride triggers cell death through destabilisation of mitochondria, but not lysosomes. Anti-cancer activity.

Chemical Name:

1'-[4-[1-(4-fluorophenyl)-1H-indole-3-yl]-1-butyl]-spiro[isobenzofuran-1(3H),4'-piperidine], hydrochloride

Sigma Receptor Related Products:

Cutamesine dihydrochloride; Blonanserin; S1RA(E-52862); Siramesine(Lu 28-179); S1RA hydrochloride

References

[1]. Cesen MH, et al. Siramesine triggers cell death through destabilisation of mitochondria, but not lysosomes. Cell Death Dis. 2013 Oct 3;4:e818.

[2]. Spirkoski J, et al. Mast cell apoptosis induced by siramesine, a sigma-2 receptor agonist. Biochem Pharmacol. 2012 Dec 15;84(12):1671-80.