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LY-335979 Zosuquidar trihydrochloride

LY-335979 Zosuquidar trihydrochloride 167465-36-3
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Chemical Information
Product name:LY-335979 Zosuquidar trihydrochloride Purity:98% min
CAS NO:167465-36-3 Solubility:DMSO : 8.33 mg/mL (15.79 mM; Need ultrasonic)
Molecular Formula:C16H24ClNO4 Package:Package according to customer requirements
Molecular Weight:329.819 Storage:Store at -20℃
Quality control
COA
Remarks

Zosuquidar, also known as LY-335979, is a potent P-glycoprotein (P-gp) inhibitor, which binds with high affinity to P-glycoprotein and inhibits P-glycoprotein-mediated multidrug resistance (MDR). P-glycoprotein, encoded by the MDR-1 gene, is a member of the ATP-binding cassette superfamily of transmembrane transporters and prevents the intracellular accumulation of many natural product-derived cytotoxic agents.

Zosuquidar 3HCl (LY335979, RS 33295-198, D06387) is a potent modulator of P-glycoprotein-mediated multi-drug resistance with Ki of 60 nM in a cell-free assay. Phase 3.

 

 

 

 

P-glycoprotein Related Products:

Elacridar; Glibenclamide; Tariquidar; Selamectin; Atazanavir; Des(benzylpyridyl) Atazanavir; Valspodar

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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