Tariquidar

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Chemical Information

Product name：Tariquidar	Purity：98% min
CAS NO：206873-63-4	Solubility：DMSO: ≥ 100 mg/mL
Molecular Formula：C₃₈H₃₈N₄O₆	Package：Package according to customer requirements
Molecular Weight：646.73	Storage：Store at -20℃

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Remarks

Tariquidar, also known as XR9576, is a P-glycoprotein (P-gp) inhibitor undergoing research as an adjuvant against multidrug resistance in cancer. Tariquidar non-competitively binds to the p-glycoprotein transporter, thereby inhibiting transmembrane transport of anticancer drugs. Inhibition of transmembrane transport may result in increased intracellular concentrations of an anticancer drug, thereby augmenting its cytotoxicity.

P-glycoprotein Related Products:

Elacridar; Glibenclamide; Zosuquidar trihydrochloride; Selamectin; Atazanavir; Des(benzylpyridyl) Atazanavir; Valspodar

References

[1]. Martin C, et al. The molecular interaction of the high affinity reversal agent XR9576 with P-glycoprotein. Br J Pharmacol, 1999, 128(2), 403-411.

[2]. Mistry P, et al. In vitro and in vivo reversal of P-glycoprotein-mediated multidrug resistance by a novel potent modulator, XR9576. Cancer Res, 2001, 61(2), 749-758.