PD98059

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Chemical Information

Product name：PD98059	Purity：98% min
CAS NO：167869-21-8	Solubility：DMSO: 16 mg/mL; H2O: < 0.01 mg/mL
Molecular Formula：C₁₆H₁₃NO₃	Package：Package according to customer requirements
Molecular Weight：267.2790	Storage：Store at -20℃

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Remarks

PD98059 also known as PD-98059, is a potent and selective inhibitor of MAP kinase kinase (also known as MAPK/ERK kinase or MEK kinase). It mediates its inhibitory properties by binding to the ERK-specific MAP kinase MEK, therefore preventing phosphorylation of ERK1/2 (p44/p42 MAPK) by MEK1/2. MAPK ERK1/2 is involved in TLR-induced production of cytokines.

Related Products:

Alpelisib; Gedatolisib; AS-604850; CAY10505; AS-605240; Apitolisib; PIK-93; PIK-75 Hydrochloride; YM201636; ZSTK474; PI-103; GNE-493; MTX-211; AKTIV; Duvelisib; TGX-221; LY294002

References

[1]. Reiners JJ Jr, et al. PD98059 is an equipotent antagonist of the aryl hydrocarbon receptor and inhibitor of mitogen-activated protein kinase kinase. Mol Pharmacol. 1998 Mar;53(3):438-45.

[2]. Alessi DR, et al. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo. J Biol Chem, 1995, 270(46), 27489-27494.