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YM201636 371942-69-7
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Chemical Information
Product name:YM201636 Purity:98% min
CAS NO:371942-69-7 Solubility:DMSO : ≥ 47 mg/mL (100.54 mM)
Molecular Formula:C25H21N7O3 Package:Package according to customer requirements
Molecular Weight:467.479 Storage:Store at -20℃
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YM201636 is an inhibitor of retroviral budding and PIKfyve-catalyzed PtdIns(3,5)P2 synthesis, and can also halt glucose entry by insulin in adipocytes. YM201636 almost completely inhibited basal and insulin-activated 2-deoxyglucose uptake at doses as low as 160 nM, with IC(50)=54+/-4 nM for the net insulin response. Insulin-induced GLUT4 translocation was partially inhibited at substantially higher doses, comparable to those required for inhibition of insulin-induced phosphorylation of Akt/PKB. In addition to PIKfyve, YM201636 also completely inhibited insulin-dependent activation of class IA PI 3-kinase.
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