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ZSTK474

ZSTK474 475110-96-4
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Chemical Information
Product name:ZSTK474 Purity:98% min
CAS NO:475110-96-4 Solubility:10 mM in DMSO
Molecular Formula:C19H21F2N7O2 Package:Package according to customer requirements
Molecular Weight:417.413 Storage:Store at -20℃
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Remarks
 ZSTK474 is a novel orally applicable phosphoinositide 3-kinase-specific inhibitor that strongly inhibits cancer cell proliferation. Combination treatment using X-rays then ZSTK474 given orally for 8 days, starting 24h post-irradiation, significantly enhanced cell growth inhibition. The combined effect was also observed for clonogenic survival with continuous ZSTK474 treatment. Western blot analysis showed enhanced phosphorylation of Akt and GSK-3β by X-irradiation, whereas phosphorylation was inhibited by ZSTK474 treatment alone. Treatment with ZSTK474 after X-irradiation also inhibited phosphorylation, and remarkably inhibited xenograft tumor growth.
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