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Bortezomib

Bortezomib 179324-69-7
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Chemical Information
Product name:Bortezomib Purity:98% min
CAS NO:179324-69-7 Solubility:DMSO:≥126.7mg/mL
Molecular Formula:C19H25BN4O4 Package:Package according to customer requirements
Molecular Weight:384.237 Storage:Store at -20℃
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Remarks

Bortezomib is a dipeptide boronic acid analogue with antineoplastic activity. Bortezomib reversibly inhibits the 26S proteasome, a large protease complex that degrades ubiquinated proteins. By blocking the targeted proteolysis normally performed by the proteasome, bortezomib disrupts various cell signaling pathways, leading to cell cycle arrest, apoptosis, and inhibition of angiogenesis. Specifically, the agent inhibits nuclear factor (NF)-kappaB, a protein that is constitutively activated in some cancers, thereby interfering with NF-kappaB-mediated cell survival, tumor growth, and angiogenesis. In vivo, bortezomib delays tumor growth and enhances the cytotoxic effects of radiation and chemotherapy.


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