EVP4593, also known as QNZ and CAY10470, is an inhibitor of NF-κB activation with an IC50 of 11 nM in human Jurkat cells. EVP4593 reduced the number of lysosomes/autophagosomes and SOC currents in HD GMSLNs and exerted neuroprotective effects during cell aging. EVP4593 may be a promising anti-HD drug.
Properties:
Appearance & Physical State: White solid
Density: 1.275g/cm3
Melting Point: 169-175ºC
Boiling Point: 602ºC at 760 mmHg
Flash Point: 317.9ºC
Refractive Index: 1.713
NF-κB Inhibitors Related Products:
Bortezomib; Bortezomib pinanediol ester; TPCA-1; Bardoxolone methyl; Curcumin; Triptolide; JSH-23; Benfotiamine; Omaveloxolone; Erdosteine