AMD 3465 hexahydrobromide

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Chemical Information

Product name：AMD 3465 hexahydrobromide	Purity：98% min
CAS NO：185991-07-5	Solubility：H2O : ≥ 38 mg/mL (42.41 mM)
Molecular Formula：C₂₄H₄₄Br₆N₆	Package：Package according to customer requirements
Molecular Weight：896.07	Storage：Store at -20℃

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Remarks

AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.

Properties:

Density: 1.022g/cm3

Boiling Point: 571.3ºC at 760 mmHg

Flash Point: 299.3ºC

Refractive Index: 1.533

Vapor Pressure: 5.1E-13mmHg at 25°C

CXCR Inhibitors Related Products:

Plerixafor (AMD3100); Plerixafor 8HCl; WZ811; Navarixin; LIT-927

References

[1]. Hatse S, et al. AMD3465, a monomacrocyclic CXCR4 antagonist and potent HIV entry inhibitor. Biochem Pharmacol. 2005 Sep 1;70(5):752-61.

[2]. Yang L, et al. Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo. Cancer Res. 2007 Jan 15;67(2):651-8.