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Product :

SCH527123 Navarixin

SCH527123 Navarixin 473727-83-2
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Chemical Information
Product name:SCH527123 Navarixin Purity:98% min
CAS NO:473727-83-2 Solubility:DMSO : ≥ 50 mg/mL (125.81 mM)
Molecular Formula:C21H23N3O5 Package:Package according to customer requirements.
Molecular Weight:397.424 Storage:Store at -20℃
Quality control
COA
Remarks

Navarixin, also known as SCH527123, PS291822 and MK-7123, is a potent CXCR2 antagonist. SCH-527123 shows antitumor activity and sensitizes cells to oxaliplatin in preclinical colon cancer models. SCH-527123 showed concentration-dependent antiproliferative effects in HCT116, Caco2, and their respective IL-8-overexpressing variants colorectal cancer cell lines. CH-527123 was able to suppress CXCR2-mediated signal transduction as shown through decreased phosphorylation of the NF-κB/mitogen-activated protein kinase (MAPK)/AKT pathway. SCH-527123 treatment decreased tumor growth and microvessel density when compared with vehicle-treated tumors.

 

 

 

CXCR Inhibitors Related Products:

Plerixafor (AMD3100); Plerixafor 8HCl; WZ811; AMD 3465 hexahydrobromide; LIT-927

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