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Product :

Pretomanid (PA-824)

Pretomanid (PA-824) 187235-37-6
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Chemical Information
Product name:Pretomanid (PA-824) Purity:98% min
CAS NO:187235-37-6 Solubility:DMSO : ≥ 33 mg/mL (91.86 mM)
Molecular Formula:C14H12F3N3O5 Package:Package according to customer requirements.
Molecular Weight:359.257 Storage:Store at -20℃
Quality control
COA
Remarks

Pretomanid, aslo known as PA-824, a bioreductive drug. PA-824 has potent in vitro activity against Mycobacterium tuberculosis. PA-824 was tested in vitro against a broad panel of multidrug-resistant clinical isolates and was found to be highly active against all isolates (MIC<1 microg/ml). PA-824 showed significant activity at 2, 10, and 50 microg/ml, similar to that of metronidazole, in a dose-dependent manner. PA-824's good activity in in vivo models, as well as its activity against multidrug-resistant M. tuberculosis and against M. tuberculosis isolates in a potentially latent state, makes PA-824 an attractive drug candidate for the therapy of tuberculosis.

 

Properties:

Density: 1.58g/cm3

Boiling Point: 462.3ºC at 760 mmHg

Flash Point: 233.4ºC

Refractive Index: 1.588

Vapor Pressure: 1E-08mmHg at 25°C

 

 

 

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Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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