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DAPT GSI-IX 208255-80-5
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Chemical Information
Product name:DAPT GSI-IX Purity:98% min
CAS NO:208255-80-5 Solubility:DMSO : ≥ 215 mg/mL (497.16 mM)
Molecular Formula:C23H26F2N2O4 Package:Package according to customer requirements
Molecular Weight:432.460 Storage:Store at -20℃
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DAPT, also known GSI-IX, is a potent and selective γ-secretase inhibitor. DAPT is a non-transition-state analogue GSI and is the compound most widely evaluated in experimental models. DAPT causes a reduction in Aβ levels in human primary neuronal cell cultures with IC50 values = 115−200 nM. DAPT blocks Notch signaling in a cell-based assay measuring the activation of the Notch pathway reporter gene with an IC50 = 500 nM. As an inhibitor of Notch, DAPT has also been used in the study of autoimmune and lymphoproliferative diseases.
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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