LY 411575, also known as LSN-411575, is potent, cell permeable and selective γ-secretase inhibitor that reduces Aβ/42 after acute or chronic treatment, and blocks Notch activation. The gamma secretase inhibitor, activating pPKC alpha intracellular pathway could be suggested to prevent or reduce downstream toxic events, representing a useful strategy to counteract Alzheimer's disease.
Gamma-secretase Inhibitors Related Products:
RO4929097; Semagacestat; Avagacestat; Dibenzazepine; Crenigacestat; DAPT (GSI-IX)