YO-01027 Dibenzazepine

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Chemical Information

Product name：YO-01027 Dibenzazepine	Purity：98% min
CAS NO：209984-56-5	Solubility：DMSO : ≥ 33 mg/mL (71.20 mM)
Molecular Formula：C₂₆H₂₃F₂N₃O₃	Package：Package according to customer requirements
Molecular Weight：463.476	Storage：Store at -20℃

Quality control

COA

Remarks

Dibenzazepine, also known as YO-01027 and Iminostilbene, is a potent γ-secretase inhibitor. Dibenzazepine also potently blocks amyloid precursor protein-like (APPL) and Notch cleavage. γ-Secretase is a fascinating, multi-subunit, intramembrane cleaving protease that is now being considered as a therapeutic target for a number of diseases. Potent, orally bioavailable γ-secretase inhibitors (GSIs) have been developed and tested in humans with Alzheimer's disease (AD) and cancer.

Properties:
Density: 1.353g/cm3
Melting Point: 257-259ºC
Boiling Point: 801.334ºC at 760 mmHg
Flash Point: 438.431ºC
Refractive Index: 1.637
Vapor Pressure: 0mmHg at 25°C

Gamma-secretase Inhibitors Related Products:

RO4929097; Semagacestat; Avagacestat; LY-411575; Crenigacestat; DAPT (GSI-IX)

References

[1]. Groth C, et al. Pharmacological analysis of Drosophila melanogaster gamma-secretase with respect to differential proteolysis of Notch and APP. Mol Pharmacol. 2010 Apr;77(4):567-74.

[2]. Fuwa H, et al. Divergent synthesis of multifunctional molecular probes to elucidate the enzyme specificity of dipeptidic gamma-secretase inhibitors. ACS Chem Biol. 2007 Jun 15;2(6):408-18.