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Tafluprost ethyl ester

Tafluprost ethyl ester 209860-89-9
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Chemical Information
Product name:Tafluprost ethyl ester Purity:98%min
CAS NO:209860-89-9 Solubility:Soluble in DMSO
Molecular Formula:C24H32F2O5 Package:Packaging according to customer requirements
Molecular Weight:438.5 Storage:Store at -20℃
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Analogs of prostaglandin F2α (PGF2α), which act primarily at the FP receptor, have been approved for the treatment of glaucoma.1,2,3,4 Tafluprost (free acid) (Item No. 10005439) is a PGF2α analog which acts as a potent FP receptor agonist (Ki = 0.4 nM).5 Tafluprost ethyl ester is a form of tafluprost which may have increased lipid solubility compared to the free acid. In addition, the ethyl ester form may demonstrate improved uptake into tissues and thus lower the effective concentration.


1. Parrish, R.K.,Palmberg, P. and Sheu, W.P. A comparison of latanoprost, bimatoprost, and travoprost in patients with elevated intraocular pressure: A 12-week, randomized, masked-evaluator multicenter study. American Journal of Ophthalmology 135, 688-703 (2003).

2. Ota, T.,Murata, H.,Sugimoto, E.i., et al. Prostaglandin analogues and mouse intraocular pressure: Effects of tafluprost, latanoprost, travoprost, and unoprostone, considering 24-hour variation. Investigative Ophthalmology & Visual Science 46(6), 2006-2011 (2005).

3. Hommer, A. and Kimmich, F. Switching patients from preserved prostaglandin-analog monotherapy to preservative-free tafluprost. Clin.Ophthalmol. 5, 623-631 (2011).

4. Januleviciene, I.,Derkac, I.,Grybauskiene, L., et al. Effects of preservative-free tafluprost on tear film osmolarity, tolerability, and intraocular pressure in previously treated patients with open-angle glaucoma. Clin.Ophthalmol. 6, 103-109 (2012).

5. Takagi, Y.,Nakajima, T.,Shimazaki, A., et al. Pharmacological characteristics of AFP-168 (tafluprost), a new prostanoid FP receptor agonist, as an ocular hypotensive drug. Experimental Eye Research 78, 767-776 (2004).

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