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Prostaglandin E2 Dinoprostone

Prostaglandin E2 Dinoprostone 363-24-6
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Chemical Information
Product name:Prostaglandin E2 Dinoprostone Purity:99%min
CAS NO:363-24-6 Solubility:Soluble in DMSO
Molecular Formula:C20H32O5 Package:Packaging according to customer requirements
Molecular Weight:352.47 Storage:Store at -20℃
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PGE2 shows inhibition of IL 2 production in the mixture of irradiated and nonirradiated T lymphocytes. PGE2 (0.1-10 μM) dose-dependently inhibits the production of IL 2. PGE2 acts during the inductive phase of activation of suppressor cells. Preincubation of T lymphocytes with PGE2 induces cells that suppress IL 2 production and PHA proliferation.

PGE2 (0.3 μg/k, i.p.) significantly reduces the number of peritoneab macrophages undergoing phagocytosis of the methacrybate microbeads in rats. PGE2 (0.1 mg/min, i.a.) increases renal blood flow. PGE2 produces a biphasic change in renal vascular resistance, vasodilatation starts at 0.01 mg/min and is maximal at about 3 mg/min, while at the highest dose used (20 mg/min) PGE2 induces renal vasoconstriction.

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