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15(S)-Latanoprost

15(S)-Latanoprost 145773-22-4
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Chemical Information
Product name:15(S)-Latanoprost Purity:95%min
CAS NO:145773-22-4 Solubility:Soluble in DMSO
Molecular Formula:C26H40O5 Package:Packaging according to customer requirements
Molecular Weight:432.59 Storage:Store at -20℃
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Remarks
15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost. The IC50 values for the free acid forms of latanoprost and 15(S)-latanoprost were determined to be 3.6 nM and 24 nM, respectively, in a FP receptor binding assay using the cat iris sphincter muscle.1 A 3 µg dose of 15(S)-latanoprost caused a 1 mmHg reduction of IOP in normotensive cynomolgus monkeys.1 15(S)-Latanoprost is a potential impurity in most commercial preparations of the latanoprost bulk drug product.
References
1. Resul, B.,Stjernschantz, J.,No, K., et al. Phenyl-substituted prostaglandins: Potent and selective antiglaucoma agents. Journal of Medicinal Chemistry 36, 243-248 (1993).
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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