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trans-Latanoprost

trans-Latanoprost 913258-34-1
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Chemical Information
Product name:trans-Latanoprost Purity:95%min
CAS NO:913258-34-1 Solubility:Soluble in DMSO
Molecular Formula:C26H40O5 Package:Packaging according to customer requirements
Molecular Weight:432.59 Storage:Store at -20℃
Quality control
COA
Remarks
Latanoprost is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug.1 5-trans Latanoprost is an isomer of latanoprost wherein the double bond between carbons 5 and 6 has been changed from cis (Z) to trans (E). The trans isomer of latanoprost occurs as an impurity of between 2-5% in most commercial preparations of the bulk drug product. The present compound was prepared primarily as an analytical standard for detection and quantitation of this impurity. From what can be inferred from the study of other trans isomers of F-type prostaglandins, 5-trans latanoprost’s biological activity is likely to be similar to that of the cis isomer. However, there are no specific published reports on the biological activity, and on the intraocular hypotensive activity in particular, of 5-trans latanoprost.
References
1. Stjernschantz, J. and Resul, B. Phenyl substituted prostaglandin analogs for glaucoma treatment. Drugs of the Future 17, 691-704 (1992).
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