D-Cloprostenol and PGF2 alpha are equipotent, about 150 times more potent than dl-cloprostenol (P < 0.05) and approximately 280 times more potent than PGE1 in inhibiting [3H]PGF2 alpha binding to corpus luteum cell membranes. However, d-cloprostenol and PGF2 alpha are about 10 times more potent than dl-cloprostenol and approximately 95 times more potent than PGE1 in myometrial cell membranes.
D-cloprostenol (15 g per head) is the lowest dose that consistently achieves abortion; D-cloprostenol causes mild adverse effects including salivation, defecation and hyperventilation in bitches weighing less than 10 kg. Intra-vesicle administration of a single low dose of d-cloprostenol is a safe and successful technique to induce abortion in the bitch.
Latanoprost Lactol; Latanoprostene bunod; Misoprostol; Carboprost; Tafluprost; Dinoprostone; Dinoprost; Trometamol; Alprostadil; Bimatoprost; (+/-)-Corey lactone diol; Beraprost sodium; Limaprost; D-Cloprostenol sodium; DL-Cloprostenol sodium; D-Cloprostenol isopropyl ester; 5,6-trans-Cloprostenol; (+)-Cloprostenol; 15S-(±)-Cloprostenol; Cloprostenol