Resatorvid (TAK-242) is a selective Toll-like receptor 4 (TLR4) inhibitor. Resatorvid inhibits NO, TNF-R and IL-6 production with IC50s of 1.8 nM, 1.9 nM and 1.3 nM, respectively.Resatorvid, also known as TAK-242, is a cell-permeable inhibitor of TLR4 signaling, blocking LPS-induced production of NO, TNF-α, IL-6, and IL-1β in macrophages with IC50 values of 1-11 nM. Resatorvid binds selectively to TLR4 and interferes with interactions between TLR4 and its adaptor molecules. Resatorvid provides neuroprotection in experimental traumatic brain injury: implication in the treatment of human brain injury.
Properties:
Density: 1.39
Boiling Point: 461.958ºC at 760 mmHg
Melting Point: 68-69ºC
Flash Point: 233.184ºC
Refractive Index:1.574
Vapor Pressure: 0mmHg at 25°C
Interleukins Inhibitors Related Products:
Aprepitant; Remibrutinib; A-740003; T-5224; YM-90709