Aprepitant MK-0869

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Chemical Information

Product name：Aprepitant MK-0869	Purity：98% min
CAS NO：170729-80-3	Solubility：DMSO : ≥ 100 mg/mL (187.12 mM)
Molecular Formula：C₂₃H₂₁F₇N₄O₃	Package：Package according to customer requirements
Molecular Weight：534.427	Storage：Store at -20℃

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Remarks

Aprepitant is a small molecule, high-affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P/neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P-induced emesis. This agent has little or no affinity for serotonin type 3 (5-HT3), dopamine, and corticosteroid receptors.

Properties:

Appearance & Physical State: Off-White to Light Yellow Cyrstalline Solid

Density: 1.51 g/cm3

Melting Point: 75-76 °C(lit.)

Refractive Index: 1.564

CSF-1R Inhibitors Related Products:

GW2580; Pazopanib; Pazopanib HCl; Linifanib; ENMD-2076; ENMD-2076 Tartrate; OSI-930; Agerafenib; Ki20227; PLX5622; Pexidartinib; Pexidartinib HCL; Erdafitinib ; BLZ945

References

[1]. Martinez AN, et al. Aprepitant limits in vivo neuroinflammatory responses in a rhesus model of Lyme neuroborreliosis. J Neuroinflammation. 2017 Feb 15;14(1):37.

[2]. Bayati S, et al. Inhibition of tachykinin NK1 receptor using aprepitant induces apoptotic cell death and G1 arrest through Akt/p53 axis in pre-B acute lymphoblastic leukemia cells. Eur J Pharmacol. 2016 Nov 15;791:274-283.