PLX3397 Pexidartinib hcl

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Chemical Information

Product name：PLX3397 Pexidartinib hcl	Purity：98% min
CAS NO：2040295-03-0	Solubility：DMSO : 60 mg/mL (132.08 mM)
Molecular Formula：C₂₀H₁₆Cl₂F₃N₅	Package：Package according to customer requirements
Molecular Weight：454.276	Storage：Store at -20℃

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Remarks

Pexidartinib hydrochloride (PLX-3397 hydrochloride) is a potent, orally active, selective, and ATP-competitive colony stimulating factor 1 receptor (CSF1R or M-CSFR) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib hydrochloride exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases. Pexidartinib hydrochloride induces cell apoptosis and has anti-cancer activity.

Related Products:

Pexidartinib; Telatinib; Avapritinib; Amuvatinib; Dovitinib Lactate; Linifanib; OSI-930; Crenolanib; Motesanib Diphosphate; Motesanib; Sunitinib; Imatinib mesylate; Axitinib; Masitinib; Dovitinib; ISCK03

References

[1]. DeNardo DG, et al. Leukocyte complexity predicts breast cancer survival and functionally regulates response to chemotherapy. Cancer Discov. 2011 Jun;1(1):54-67.

[2]. Kuse Y, et al. Microglia increases the proliferation of retinal precursor cells during postnatal development. Mol Vis. 2018 Jul 30;24:536-545. eCollection 2018.