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Imatinib mesylate

Imatinib mesylate  220127-57-1
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Chemical Information
Product name:Imatinib mesylate Purity:98% min
CAS NO:220127-57-1 Solubility:Soluble in DMSO
Molecular Formula:C30H35N7O4S Package:Package according to customer requirements
Molecular Weight:589.71 Storage:Store at -20℃
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Remarks

Imatinib mesylate is the mesylate salt of imatinib, a tyrosine kinase inhibitor with antineoplastic activity. Imatinib binds to an intracellular pocket located within tyrosine kinases (TK), thereby inhibiting ATP binding and preventing phosphorylation and the subsequent activation of growth receptors and their downstream signal transduction pathways. This agent inhibits TK encoded by the bcr-abl oncogene as well as receptor TKs encoded by the c-kit and platelet-derived growth factor receptor (PDGFR) oncogenes. Imatinib is used for chronic myelogenous leukemia (CML) and acute lymphocytic leukemia (ALL) that are Philadelphia chromosome-positive (Ph+) and certain types of gastrointestinal stromal tumors (GIST), systemic mastocytosis, and myelodysplastic syndrome.


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