PLX3397 Pexidartinib

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Chemical Information

Product name：PLX3397 Pexidartinib	Purity：98% min
CAS NO：1029044-16-3	Solubility：DMSO : 5 mg/mL (11.97 mM); H2O : < 0.1 mg/mL
Molecular Formula：C₂₀H₁₅ClF₃N₅	Package：Package according to customer requirements
Molecular Weight：417.815	Storage：Store at -20℃

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Remarks

Pexidartinib (PLX-3397) is a potent, selective and ATP-competitive CSF1R (cFMS) and c-Kit inhibitor, with IC₅₀s of 20 and 10 nM, respectively. Pexidartinib exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases, such as FLT3, KDR (VEGFR2), LCK, FLT1 (VEGFR1) and NTRK3 (TRKC), with IC₅₀s of 160, 350, 860, 880, and 890 nM, respectively.

Related Products:

Pexidartinib hcl; Telatinib; Avapritinib; Amuvatinib; Dovitinib Lactate; Linifanib; OSI-930; Crenolanib; Motesanib Diphosphate; Motesanib; Sunitinib; Imatinib mesylate; Axitinib; Masitinib; Dovitinib; ISCK03

References

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[2]. Kuse Y, et al. Microglia increases the proliferation of retinal precursor cells during postnatal development. Mol Vis. 2018 Jul 30;24:536-545. eCollection 2018.