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PLX3397 Pexidartinib

PLX3397 Pexidartinib 1029044-16-3
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Chemical Information
Product name:PLX3397 Pexidartinib Purity:98% min
CAS NO:1029044-16-3 Solubility:DMSO : 5 mg/mL (11.97 mM); H2O : < 0.1 mg/mL
Molecular Formula:C20H15ClF3N5 Package:Package according to customer requirements
Molecular Weight:417.815 Storage:Store at -20℃
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Remarks

Pexidartinib (PLX-3397) is a potent, selective and ATP-competitive CSF1R (cFMS) and c-Kit inhibitor, with IC50s of 20 and 10 nM, respectively. Pexidartinib exhibits 10- to 100-fold selectivity for c-Kit and CSF1R over other related kinases, such as FLT3, KDR (VEGFR2), LCK, FLT1 (VEGFR1) and NTRK3 (TRKC), with IC50s of 160, 350, 860, 880, and 890 nM, respectively.

 

 

 

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Pexidartinib hcl; Telatinib; Avapritinib; Amuvatinib; Dovitinib Lactate; Linifanib; OSI-930; Crenolanib; Motesanib Diphosphate; Motesanib; Sunitinib; Imatinib mesylate; Axitinib; Masitinib; Dovitinib; ISCK03

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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