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Amuvatinib MP-470

Amuvatinib MP-470 850879-09-3
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Chemical Information
Product name:Amuvatinib MP-470 Purity:98% min
CAS NO:850879-09-3 Solubility:10 mM in DMSO
Molecular Formula:C23H21N5O3S Package:Package according to customer requirements
Molecular Weight:447.51 Storage:Store at -20℃
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Remarks
Amuvatinib, also known as MP-470, is an orally bioavailable synthetic carbothioamide with potential antineoplastic activity. Multitargeted receptor tyrosine kinase inhibitor MP470 binds to mutant forms of the stem cell factor receptor (c-Kit; SCFR), inhibiting clinically relevant mutants of this receptor tyrosine kinase that may be associated with resistance to therapy. In addition, MP470 inhibits activities of other receptor tyrosine kinases, such as c-Met, Ret oncoprotein, and mutant forms of Flt3 and PDGFR alpha, which are frequently dysregulated in variety of tumors.
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