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Linifanib ABT-869

Linifanib ABT-869 796967-16-3
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Chemical Information
Product name:Linifanib ABT-869 Purity:98% min
CAS NO:796967-16-3 Solubility:DMSO: ≥ 72 mg/mL
Molecular Formula:C21H18FN5O Package:Packaging according to customer requirements
Molecular Weight:375.399 Storage:Store at -20℃
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Remarks
Linifanib, also known as ABT-869, is an orally bioavailable, small-molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Linifanib inhibits members of the vascular endothelial growth factor (VEGF) and platelet-derived growth factor (PDGF) receptor families; it exhibits much less activity against unrelated RTKs, soluble tyrosine kinases, or serine/threonine kinases. This agent does not have a general antiproliferative effect due to its high dose requirement. However, linifanib may exhibit potent antiproliferative and apoptotic effects on tumor cells whose proliferation is dependent on mutant kinases, such as fms-related tyrosine kinase receptor-3 (FLT3).
Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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