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Sunitinib  557795-19-4
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Chemical Information
Product name:Sunitinib Purity:98% min
CAS NO:557795-19-4 Solubility:Soluble in DMSO, not in water
Molecular Formula:C22H23D4FN4O2 Package:Package according to customer requirements
Molecular Weight:402.498 Storage:Store at -20℃
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Sunitinib free base is an oral, small-molecule, multi-targeted receptor tyrosine kinase (RTK) inhibitor. Sunitinib malate salt was approved by the FDA for the treatment of renal cell carcinoma (RCC) and imatinib-resistant gastrointestinal stromal tumor (GIST) on January 26, 2006. Sunitinib inhibits cellular signaling by targeting multiple receptor tyrosine kinases (RTKs). The simultaneous inhibition of these targets therefore reduces tumor vascularization and triggers cancer cell apoptosis and thus results in tumor shrinkage. Sunitinib also inhibits CD117 (c-KIT), the receptor tyrosine kinase that (when improperly activated by mutation) drives the majority of gastrointestinal stromal cell tumors.
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