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Pazopanib HCl (GW786034 HCl)

Pazopanib HCl (GW786034 HCl) 635702-64-6
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Chemical Information
Product name:Pazopanib HCl (GW786034 HCl) Purity:99% min
CAS NO:635702-64-6 Solubility:DMSO : 10 mg/mL (21.10 mM; Need ultrasonic)
Molecular Formula:C21H23N7O2S.HCl Package:Packaging according to customer requirements.
Molecular Weight:473.98 Storage:Store at -20℃
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COA
Remarks

Pazopanib HCl (GW786034 HCl) is a novel multi-target inhibitor of VEGFR1, VEGFR2, VEGFR3, PDGFR, FGFR, c-Kit and c-Fms with IC50 of 10 nM, 30 nM, 47 nM, 84 nM, 74 nM, 140 nM and 146 nM in cell-free assays, respectively. Pazopanib induces autophagic Type II cell death.

 

In vitro:

Pazopanib potently inhibits VEGF-induced phosphorylation of VEGFR2 in HUVEC cells with IC50 of 8 nM. Pazopanib shows dose-dependent growth inhibition in all synovial sarcoma cell lines including SYO-1 and HS-SY-II cells. Proliferation of SYO-1 and HS-SY-II cells is inhibited even at 1 µg/mL of Pazopanib and is completely abolished at 5 µg/mL. Pazopanib induces G1 arrest, and thereby suppresses the growth of synovial sarcoma cells. Phosphorylation of Akts, GSK-3β, JNKs, p70 S6 Kinase, and mTOR is suppressed in Pazopanib-treated SYO-1 cells compared with that in the vehicle-treated cells. Pazopanib between 20 m g/mL and 22.5 m g/mL shows an increasing reduction of RPE cell viability.

 

 

 

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