Sorafenib

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：Sorafenib	Purity：98% min
CAS NO：284461-73-0	Solubility：DMSO: ≥ 45 mg/mL
Molecular Formula：C₂₁H₁₆ClF₃N₄O₃	Package：Package according to customer requirements.
Molecular Weight：464.825	Storage：Store at -20℃

Quality control

COA

Remarks

Sorafenib is a synthetic compound targeting growth signaling and angiogenesis. Sorafenib blocks the enzyme RAF kinase, a critical component of the RAF/MEK/ERK signaling pathway that controls cell division and proliferation; in addition, sorafenib inhibits the VEGFR-2/PDGFR-beta signaling cascade, thereby blocking tumor angiogenesis. Sorafenib was approved in 2005 for use in the treatment of advanced renal cancer.

Properties:
Appearance & Physical State: White to off-white solid
Density: 1.454 g/cm3
Melting Point: 225-235ºC
Boiling Point: 523.3ºC at 760 mmHg
Flash Point: 270.3ºC
Vapor Pressure: 4.76E-11mmHg at 25°C

Related Prodcuts:

Sunitinib malate; Cabozantinib; Cabozantinib malate; Ponatinib; Axitinib; Vandetanib; Nintedanib; Regorafenib; Pazopanib HCl; Pazopanib; Cediranib; Dovitinib; Lenvatinib; Tivozanib; Sorafenib Tosylate

References

[1]. Wilhelm SM, et al. BAY 43-9006 exhibits broad spectrum oral antitumor activity and targets the RAF/MEK/ERK pathway and receptor tyrosine kinases involved in tumor progression and angiogenesis. Cancer Res. 2004 Oct 1;64(19):7099-109.

[2]. Huynh H, et al. Sorafenib and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. J Cell Mol Med. 2009 Aug;13(8B):2673-83.

[3]. El-Ashmawy NE, et al. Sorafenib effect on liver neoplastic changes in rats: more than a kinase inhibitor. Clin Exp Med. 2016 Apr 16.