Pazopanib

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Chemical Information

Product name：Pazopanib	Purity：99% min
CAS NO：444731-52-6	Solubility：DMSO : ≥ 43 mg/mL (98.28 mM)
Molecular Formula：C₂₁H₂₃N₇O₂S	Package：Packaging according to customer requirements.
Molecular Weight：437.52	Storage：Store at -20℃

Quality control

Remarks

Pazopanib is an approved drug, is a small molecule inhibitor of multiple protein tyrosine kinases with potential antineoplastic activity. Pazopanib selectively inhibits vascular endothelial growth factor receptors (VEGFR)-1, -2 and -3, c-kit and platelet derived growth factor receptor (PDGF-R), which may result in inhibition of angiogenesis in tumors in which these receptors are upregulated. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus).

Properties:

Appearance & Physical State: White powder

Density: 1.4

Boiling Point: 728.8ºC at 760 mmHg

Flash Point: 394.6ºC

Related Prodcuts:

Sorafenib; Cabozantinib; Cabozantinib malate; Axitinib; Vandetanib; Nintedanib; Regorafenib; Pazopanib HCl; Cediranib; Dovitinib; Lenvatinib; Tivozanib; Sorafenib Tosylate; Sunitinib Malate

References

[1]. Harris PA, et al. Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. J Med Chem. 2008, 51(15), 4632-4640.

[2]. Thakur A, et al. Pazopanib, a multitargeted tyrosine kinase inhibitor, reduces diabetic retinal vascular leukostasis and leakage. Microvasc Res. 2011 Nov;82(3):346-50.