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Lenvatinib (E7080)

Lenvatinib (E7080) 417716-92-8
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Chemical Information
Product name:Lenvatinib (E7080) Purity:99% min
CAS NO:417716-92-8 Solubility:Soluble in DMSO
Molecular Formula:C21H19ClN4O4 Package:Packaging according to customer requirements
Molecular Weight:426.85 Storage:Store at -20℃
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Remarks

Lenvatinib (E7080) is a multi-target inhibitor, mostly for VEGFR2(KDR)/VEGFR3(Flt-4) with IC50 of 4 nM/5.2 nM, less potent against VEGFR1/Flt-1, ~10-fold more selective for VEGFR2/3 against FGFR1, PDGFRα/β in cell-free assays. Lenvatinib (E7080) also inhibits FGFR1-4, PDGFR, Kit (c-Kit), RET (c-RET), and shows potent antitumor activities. Phase 3.

 

E7080, as a potent inhibitor of in vitro angiogenesis, shows a significantly inhibitory effect on VEGF/KDR and SCF/Kit signaling. According to the in vitro receptor tyrosine and serine/threonine kinase assays, E7080 inhibits Flt-1, KDR, Flt-4 with IC50 of 22, 4.0 and 5.2 nM, respectively. In addition to these kinases, E7080 also inhibits FGFR1 and PDGFR tyrosine kinases with IC50 value of 46, 51 and 100 nM for FGFR1, PDGFRα and PDGFRβ, respectively. E7080 potently inhibits phosphorylation of VEGFR2 (IC50, 0.83 nM) and VEGFR3 (IC50, 0.36 nM) in HUVECs which is stimulated by VEGF and VEGF-C, respectively. A recent study shows that E7080 treatment (both at 1 μM and 10 μM) results in a significant inhibition of cell migration and invasion by inhibiting FGFR and PDGFR signaling.

 

 

 

 

FGFR Inhibitors Related Products:

Infigratinib; PD173074; AZD4547; Danusertib; Brivanib alaninate; Pemigatinib; Lenvatinib mesylate; Nintedanib esylate; BLU9931; SKLB610; Roblitinib

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.
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