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PD173074

PD173074 219580-11-7
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Chemical Information
Product name:PD173074 Purity:98% min
CAS NO:219580-11-7 Solubility:DMSO: ≥ 52 mg/mL
Molecular Formula:C28H41N7O3 Package:Package according to customer requirements
Molecular Weight:523.670 Storage:Store at -20℃
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Remarks
PD173074 is a small-molecule FGFR3-selective tyrosine kinase inhibitor (TKI), as a therapeutic modality using eight UC cell lines. PD173074 suppressed cell proliferation remarkably in two cell lines, namely, UM-UC-14 and MGHU3, which expressed mutated FGFR3 protein. Cell cycle analysis revealed the growth inhibitory effect of PD173074 was associated with arrest at G(1)-S transition in a dose-depending manner. In the mouse xenograft models using subcutaneously transplanted UM-UC-14 and MGHU3, orally administered PD173074 suppressed tumor growth and induced apoptotic changes comparable with the results of our in vitro assay.
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