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Nintedanib esylate

Nintedanib esylate 656247-18-6
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Chemical Information
Product name:Nintedanib esylate Purity:98% min
CAS NO:656247-18-6 Solubility:92.85 mg/mL (142.90 mM)
Molecular Formula:C33H39N5O7S Package:Package according to customer requirements
Molecular Weight:649.757 Storage:Store at -20℃
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Nintedanib, also known as BIBF1120, is a potent inhibitor of multiple receptor tyrosine kinases (RTKs) and non-receptor tyrosine kinases (nRTKs). Nintedanib inhibits the following RTKs: platelet-derived growth factor receptor (PDGFR) α and β, fibroblast growth factor receptor (FGFR) 1-3, vascular endothelial growth factor receptor (VEGFR) 1-3, and Fms-like tyrosine kinase-3 (FLT3). Nintedanib binds competitively to the adenosine triphosphate (ATP) binding pocket of these receptors and blocks the intracellular signaling which is crucial for the proliferation, migration, and transformation of fibroblasts representing essential mechanisms of the IPF pathology. Nintedanib esylate was approved in 2014 for the treatment of idiopathic pulmonary fibrosis (IPF).


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