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Lenvatinib mesylate

Lenvatinib mesylate 857890-39-2
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Chemical Information
Product name:Lenvatinib mesylate Purity:98% min
CAS NO:857890-39-2 Solubility:Soluble in DMSO, not in water
Molecular Formula:C22H23ClN4O7S Package:Package according to customer requirements
Molecular Weight:522.959 Storage:Store at -20℃
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Lenvatinib, also known as E7080, is a synthetic, orally available inhibitor of vascular endothelial growth factor receptor 2 (VEGFR2, also known as KDR/FLK-1) tyrosine kinase with potential antineoplastic activity. E7080 blocks VEGFR2 activation by VEGF, resulting in inhibition of the VEGF receptor signal transduction pathway, decreased vascular endothelial cell migration and proliferation, and vascular endothelial cell apoptosis.



1: Wirth LJ, Tahara M, Robinson B, Francis S, Brose MS, Habra MA, Newbold K, Kiyota N, Dutcus CE, Mathias E, Guo M, Sherman SI, Schlumberger M. Treatment-emergent hypertension and efficacy in the phase 3 Study of (E7080) lenvatinib in differentiated cancer of the thyroid (SELECT). Cancer. 2018 Apr 14. doi: 10.1002/cncr.31344. [Epub ahead of print] PubMed PMID: 29656442.

2: Cavalieri S, Cosmai L, Genderini A, Nebuloni M, Tosoni A, Favales F, Pistillo P, Bergamini C, Bossi P, Licitra L, Locati LD, Alfieri S. Lenvatinib-induced renal failure: two first-time case reports and review of literature. Expert Opin Drug Metab Toxicol. 2018 Apr 13:1-7. doi: 10.1080/17425255.2018.1461839. [Epub ahead of print] PubMed PMID: 29617171.

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