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Cabozantinib (XL184)

Cabozantinib (XL184) 849217-68-1
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Chemical Information
Product name:Cabozantinib (XL184) Purity:98% min
CAS NO:849217-68-1 Solubility:DMSO : ≥ 30 mg/mL (59.82 mM)
Molecular Formula:C28H24FN3O5 Package:Packaging according to customer requirements.
Molecular Weight:501.51 Storage:Store at -20℃
Quality control
COA
Remarks

Cabozantinib, also known as XL-184 or BMS-907351, is an orally bioavailable, small molecule receptor tyrosine kinase (RTK) inhibitor with potential antineoplastic activity. Cabozantinib strongly binds to and inhibits several tyrosine receptor kinases. Specifically, cabozantinib appears to have a strong affinity for the hepatocyte growth factor receptor (Met) and vascular endothelial growth factor receptor 2 (VEGFR2), which may result in inhibition of tumor growth and angiogenesis, and tumor regression. Cabozantinib was approved by the U.S. FDA in November 2012 for the treatment of medullary thyroid cancer.

 

 

 

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