ENMD-2076 Tartrate

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Chemical Information

Product name：ENMD-2076 Tartrate	Purity：98% min
CAS NO：1291074-87-7	Solubility：Soluble in DMSO
Molecular Formula：C₂₅H₃₁N₇O₆	Package：Package according to customer requirements.
Molecular Weight：525.557	Storage：Store at -20℃

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Remarks

ENMD-2076 has selective activity against Aurora A and Flt3 with IC50 of 14 nM and 1.86 nM, 25-fold selective for Aurora A than over Aurora B and less potent to RET, SRC, NTRK1/TRKA, CSF1R/FMS, VEGFR2/KDR, FGFR and PDGFRα. ENMD-2076 inhibits the growth of a wide range of human solid tumor and hematopoietic cancer cell lines with IC50 from 0.025 to 0.7 μM, which induces apoptosis and G2/M phase arrest.

ENMD-2076 Tartrate is a multi-targeted kinase inhibitor with IC₅₀s of 1.86, 14, 58.2, 15.9, 92.7, 70.8, 56.4 nM for Aurora A, Flt3, KDR/VEGFR2,Flt4/VEGFR3, FGFR1, FGFR2, Src, PDGFRα, respectively.

CSF-1R Inhibitors Related Products:

GW2580; Pazopanib; Pazopanib HCl; Linifanib; ENMD-2076 Tartrate; OSI-930; Agerafenib; Ki20227; PLX5622; Pexidartinib; Pexidartinib HCL; Aprepitant; Erdafitinib; BLZ945

References

[1]. Fletcher GC, et al. ENMD-2076 is an orally active kinase inhibitor with antiangiogenic and antiproliferative mechanisms of action. Mol Cancer Ther. 2011 Jan;10(1):126-37.

[2]. Wang X, et al. Preclinical activity of a novel multiple tyrosine kinase and aurora kinase inhibitor, ENMD-2076, against multiple myeloma. Br J Haematol. 2010 Aug;150(3):313-25.