PLX5622

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Chemical Information

Product name：PLX5622	Purity：98% min
CAS NO：1303420-67-8	Solubility：DMSO : 100 mg/mL (252.90 mM)
Molecular Formula：C₂₁H₁₉F₂N₅O	Package：Package according to customer requirements
Molecular Weight：395.405	Storage：Store at -20℃

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Remarks

PLX5622 is a highly selective brain penetrant and oral active CSF1R inhibitor. PLX5622 has been shown to eliminate microglia from the brain, which can be sustained in wild-type and the Alzheimer's disease model mice (3xTg-AD model). In the AD model PLX5622 prevents microglial association with amyloid β plaques and improves cognition.

CSF-1R Inhibitors Related Products:

GW2580; Pazopanib; Pazopanib HCl; Linifanib; ENMD-2076; ENMD-2076 Tartrate; OSI-930; Agerafenib; Ki20227; Pexidartinib; Pexidartinib HCL; Aprepitant; Erdafitinib ; BLZ945

References

[1]. Spangenberg E, et al. Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer's disease model. Nat Commun. 2019 Aug 21;10(1):3758.

[2]. Lee S, et al. Targeting macrophage and microglia activation with colony stimulating factor 1 receptor inhibitor is an effective strategy to treat injury-triggered neuropathic pain. Mol Pain. 2018 Jan-Dec;14:1744806918764979.