T-5224

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Chemical Information

Product name：T-5224	Purity：98% min
CAS NO：530141-72-1	Solubility：DMSO : ≥ 31 mg/mL (59.90 mM)
Molecular Formula：C₂₉H₂₇NO₈	Package：Package according to customer requirements
Molecular Weight：517.527	Storage：Store at -20℃

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Remarks

T-5224 is a selective inhibitor of c-Fos/activator protein-1. T-5224 ameliorates liver injury and improves survival through decreasing production of proinflammatory cytokines and chemokines in endotoxemic mice. T-5224 has been investigated in phase II human clinical trials. T-5224 may be a promising new treatment for septic kidney injury. Activator protein 1 (AP-1) is a pivotal transcription factor that regulates a wide range of cellular processes including proliferation, apoptosis, differentiation, survival, cell migration, and transformation.

MMP Inhibitors Related Products:

Batimastat; Ilomastat; MMP-9-IN-1; NSC-405020; TAPI-1 ; Marimastat

References

[1]. Uchihashi S, et al. Metabolism of the c-Fos/activator protein-1 inhibitor T-5224 by multiple human UDP-glucuronosyltransferase isoforms. Drug Metab Dispos. 2011 May;39(5):803-13.

[2]. Miyazaki H, et al. The effects of a selective inhibitor of c-Fos/activator protein-1 on endotoxin-induced acute kidney injury in mice. BMC Nephrol. 2012 Nov 23;13:153.

[3]. Izuta S, et al. T-5224, a selective inhibitor of c-Fos/activator protein-1, attenuates lipopolysaccharide-induced liver injury in mice. Biotechnol Lett. 2012 Dec;34(12):2175-82.