BB94 Batimastat

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Chemical Information

Product name：BB94 Batimastat	Purity：98% min
CAS NO：130370-60-4	Solubility：DMSO : 50 mg/mL (104.68 mM)
Molecular Formula：C₂₃H₃₁N₃O₄S₂	Package：Package according to customer requirements.
Molecular Weight：477.64	Storage：Store at -20℃

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Remarks

Batimastat (also known as BB-94) is a synthetic matrix metalloproteinase inhibitor that has shown antineoplastic and antiangiogenic activity in various tumor models. Matrix metalloproteinases (MMPs) are thought to play a significant role in tumor invasion and metastasis as well as angiogenesis. Batimastat, also known as BB-94, acts as an inhibitor of metalloproteinase activity by binding the zinc ion in the active site of MMPs.

MMP Inhibitors Related Products:

Ilomastat; MMP-9-IN-1; NSC-405020; T-5224; TAPI-1; Marimastat

References

[1]. Yin Z, et al. Increased MMPs expression and decreased contraction in the rat myometrium during pregnancy and in response to prolonged stretch and sex hormones. Am J Physiol Endocrinol Metab. 2012 Jul 1;303(1):E55-70.

[2]. Botos I, et al. Batimastat, a potent matrix mealloproteinase inhibitor, exhibits an unexpected mode of binding. Proc Natl Acad Sci U S A. 1996 Apr 2;93(7):2749-54.

[3]. Hansen HP, et al. Inhibition of metalloproteinases enhances the internalization of anti-CD30 antibody Ki-3 and the cytotoxic activity of Ki-3 immunotoxin. Int J Cancer. 2002 Mar 10;98(2):210-5.