Ilomastat GM6001

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Chemical Information

Product name：Ilomastat GM6001	Purity：98% min
CAS NO：142880-36-2	Solubility：DMSO : ≥ 47 mg/mL (120.99 mM)
Molecular Formula：C₂₀H₂₈N₄O₄	Package：Package according to customer requirements.
Molecular Weight：388.461	Storage：Store at -20℃

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Remarks

Ilomastat, also known as GM6001 and galardin, is a broad-spectrum matrix metalloproteinase inhibitor with potential anticancer activity. GM6001 is a member of the hydroxamic acid class of reversible metallopeptidase inhibitors. The anionic state of the hydroxamic acid group forms a bidentate complex with the active site zinc. Examples of enzymes that ilomastat inhibit include thermolysin, peptide deformylase, and anthrax lethal factor endopeptidase (LF) produced by the bacterium Bacillus anthracis.

MMP Inhibitors Related Products:

Batimastat; MMP-9-IN-1; NSC-405020; T-5224; TAPI-1; Marimastat

References

[1]. Grobelny D, et al. Inhibition of human skin fibroblast collagenase, thermolysin, and Pseudomonas aeruginosa elastase by peptide hydroxamic acids. Biochemistry. 1992 Aug 11;31(31):7152-4.

[2]. Schultz GS, et al. Treatment of alkali-injured rabbit corneas with a synthetic inhibitor of matrix metalloproteinases. Invest Ophthalmol Vis Sci. 1992 Nov;33(12):3325-31.