NSC 405020

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Chemical Information

Product name：NSC 405020	Purity：98% min
CAS NO：7497-07-6	Solubility：DMSO : ≥ 260 mg/mL (999.38 mM)
Molecular Formula：C₁₂H₁₅Cl₂NO	Package：Package according to customer requirements
Molecular Weight：260.160	Storage：Store at -20℃

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Remarks

NSC-405020 is a Membrane type-1 matrix metalloproteinase (MT1-MMP) inhibitor (IC50 > 100 μmol/L). Inhibition of MT1-MMP expression by NSC405020 resulted in decrease of arsenic-mediated invasion of HSC5 cells involving decrease in phosphorylated extracellular signal-regulated kinases (pERK).

Properties:
Density: 1.182g/cm3
Boiling Point: 353.7ºC at 760 mmHg
Flash Point: 167.7ºC
Refractive Index: 1.531

MMP Inhibitors Related Products:

Batimastat; Ilomastat; MMP-9-IN-1; T-5224; TAPI-1 ; Marimastat

References

[1]. Remacle AG, et al. Novel MT1-MMP small-molecule inhibitors based on insights into hemopexin domain function in tumor growth. Cancer Res. 2012 May 1;72(9):2339-49.