Carbamazepine

Carbamazepine is a medication used primarily in the treatment of epilepsy and neuropathic pain. For seizures it works as well as phenytoin and valproate. It is not effective for absence seizures or myoclonic seizures. It may be used in schizophrenia along with other medications and as a second line agent in bipolar disorder. It is taken two to four times per day. A controlled release formulation is available for which there is tentative evidence showing less side effects.

Properties:
Appearance & Physical State: white to off-white powder
Density: 1.266g/cm3
Melting Point: 189-192ºC
Boiling Point: 411ºC at 760mmHg
Flash Point: 202.4ºC
Refractive Index: 1.669
Water Solubility: pract. insoluble
Stability: Stable under normal temperatures and pressures.

Vapor Pressure: 5.78E-07mmHg at 25°C

Sodium Channel Inhibitors Related Products:  

A-803467; Camostat Mesilate; Ambroxol hcl; Proparacaine hydrochloride; Rufinamide; Zonisamide; Zonisamide sodium salt; Dronedarone hcl; Baricitinib; Levobupivacaine; Levobupivacaine hcl; Vinpocetine; Propafenone hcl; Lamotrigine

[1]. Willow, M. and W.A. Catterall, Inhibition of binding of [3H]batrachotoxinin A 20-alpha-benzoate to sodium channels by the anticonvulsant drugs diphenylhydantoin and carbamazepine. Mol Pharmacol, 1982. 22(3): p. 627-35.

[2]. Okada, M., et al., Biphasic effects of carbamazepine on the dopaminergic system in rat striatum and hippocampus. Epilepsy Res, 1997. 28(2): p. 143-53.