TLR4-IN-C34

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Chemical Information

Product name：TLR4-IN-C34	Purity：98% min
CAS NO：40592-88-9	Solubility：DMSO : 250 mg/mL (642.01 mM)
Molecular Formula：C₁₇H₂₇NO₉	Package：Package according to customer requirements.
Molecular Weight：389.398	Storage：-20 ℃

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Remarks

TLR4-IN-C34 is an orally active inhibitor of TLR4 and reduces systemic inflammation in models of endotoxemia and necrotizing enterocolitis.

Synonyms:

(2R,3S,4R,5R,6S)-5-acetamido-2-(acetoxymethyl)-6-isopropoxytetrahydro-2H-pyran-3,4-diyl diacetate

TLR Inhibitors Related Products:

AMG9810; Resatorvid; Resiquimod

References

[1]. Neal MD, et al. Discovery and validation of a new class of small molecule Toll-like receptor 4 (TLR4) inhibitors. PLoS One. 2013 Jun 12;8(6):e65779.

[2]. Wipf P, et al. Synthesis of anti-inflammatory α-and β-linked acetamidopyranosides as inhibitors of toll-like receptor 4 (TLR4). Tetrahedron Lett. 2015 Jun 3;56(23):3097-3100.