R1487 HCl

Size	Price	Stock	Quantity
Get Quotation Now Add to Cart Bulk Inquiry

Shipping and handling fee USD40, Free delivery is qualified when the total value of your order exceeds USD500.If the item is temporarily out of stock. Please email to order@pharm-intermediates.com,we will inform you when we have it in stock.

Chemical Information

Product name：R1487 HCl	Purity：98% min
CAS NO：449808-64-4	Solubility：DMSO : 20.83 mg/mL (49.03 mM)
Molecular Formula：C₁₉H₁₉ClF₂N₄O₃	Package：Package according to customer requirements
Molecular Weight：424.829	Storage：Store at -20℃

Quality control

Remarks

R1487 (Hydrochloride) is highly potent and highly selective inhibitors of p38α.

Synonyms:
R-1487 Hydrochloride;
6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one hydrochloride;
Pyrido[2,3-d]pyrimidin-7(8H)-one,6-(2,4-difluorophenoxy)-8-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-,hydrochloride;
QC-6149;
RS0052;

p38 MAPK Inhibitors Related Products:

SB203580; Doramapimod; SB-202190; VX-702; PH-797804; Neflamapimod; TAK-715; SB239063; Losmapimod ; Ralimetinib dimesylate

References

[1]. Goldstein DM et al. Discovery of 6-(2,4-difluorophenoxy)-2-[3-hydroxy-1-(2-hydroxyethyl)propylamino]-8-methyl-8H-pyrido[2,3-d]pyrimidin-7-one (pamapimod) and 6-(2,4-difluorophenoxy)-8-methyl-2-(tetrahydro-2H-pyran-4-ylamino)pyrido[2,3-d]pyrimidin-7(8H)-one (R1487) as orally bioavailable and highly selective inhibitors of p38α mitogen-activated protein kinase. J Med Chem. 2011 Apr 14;54(7):2255-65.