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PH-797804 586379-66-0
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Chemical Information
Product name:PH-797804 Purity:98% min
CAS NO:586379-66-0 Solubility:10 mM in DMSO
Molecular Formula:C22H19BrF2N2O3 Package:Package according to customer requirements
Molecular Weight:477.299 Storage:Store at -20℃
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PH-797804 is a potent and selectiove inhibitor of p38 mitogen-activated protein (MAP) kinase. PH-797804 reduces tumor growth of the three PDXs, which correlates with impaired colon tumor cell proliferation and survival. The inhibition of p38 MAPK in PDXs results in downregulation of the IL-6/STAT3 signaling pathway, which is a key regulator of colon tumorigenesis. PH-797804 may have therapeutic interest for colon cancer treatment.
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