Alpha-Estradiol (17 alpha-Estradiol) is a 5α-reductase inhibitor, and inhibits testosterone metabolism catalyzed by 5 alpha-reductase. Alpha-Estradiol (17 Alpha-estradiol, 10 μM) attenuates LPS-induced inflammatory markers in both C57BL/6J male and female mouse embryonic fibroblast (MEF) cells, primary pre-adipocytes and differentiated 3T3-L1 adipocytes in an ERα-dependent manner, and such effects are through decreased NFκB-p65 and increased ERα protein expression.
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2-methoxyestradiol; Estradiol valerate; Estradiol enantate; Estradiol benzoate; Estradiol cypionate; Estradiol hemihydrate; Ethynyl estradiol; Estradiol; Calcifediol; Calcifediol monohydrate